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2007/01/29 Monday

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2007/01/25 Thursday

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2007/01/25(Thu)
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G59A, T211C, C268T, A539G, C796T, T868C, A1300G, C1330T, G1562T, C1618T.

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¡ÖKanai, Y., Sato, F., Ueta, M., Minton, J., Higuchi, H., Soma, M., Mita, N. and Matsui, S. 1997. The migration routes and important restsites of Whooper Swans satellite-tracked from northern Japan¡×

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¡ÖH5N1 Qinghai Emergence in Mongolia ¡×¤è¤ê°úÍÑ(ÂÀ»ú¤¬¡¢¥â¥ó¥´¥ë¤Î¥ª¥ª¥Ï¥¯¥Á¥ç¥¦¤Î¥¦¥£¥ë¥¹)
»²¹Í¡ÖEvolution of H5N1 Headlines ¡×

G59A

AB263752 A/whooper swan/Mongolia/2/06 2006 H5N1 DQ343150 A/chicken/Hebei/326/2005 2005 H5N1
DQ320915 A/goose/Shantou/2216/2005 2005 H5N1
AY609312 A/chicken/Guangdong/174/04 2004 H5N1
AY737289 A/chicken/Guangdong/191/04 2004 H5N1
DQ343151 A/chicken/Hebei/718/2001 2001 H5N1
AY585365 A/duck/Guangxi/35/2001 2001 H5N1

T211C

DQ661910 A/chicken/Afghanistan/1207/2006 2006 H5N1
DQ676834 A/chicken/Krasnodar/01/2006 2006 H5N1
DQ440535 A/swan/Iran/754/2006 2006 H5N1
DQ412997 A/swan/Italy/179/06 2006 H5N1
ISDN136919 A/swan/Italy/179/2006 2006 H5N1
AB263752 A/whooper swan/Mongolia/2/06 2006 H5N1

C268T

DQ661910 A/chicken/Afghanistan/1207/2006 2006 H5N1
AB263752 A/whooper swan/Mongolia/2/06 2006 H5N1 ISDN124038 A/Chicken/Viet Nam/NCVD09/2005 2005 H5N1
ISDN124037 A/Chicken/Viet Nam/NCVD10/2005 2005 H5N1
AM183674 A/chicken/Vietnam/P22/05 2005 H5N1
AM183673 A/chicken/Vietnam/P78/05 2005 H5
DQ497674 A/duck/Vietnam/272/2005 2005 H5N1
AM183676 A/duck/Vietnam/AG40-O2/05 2005 H5
DQ497677 A/mallard/Vietnam/352/2005 2005 H5N1
ISDN111351 A/Chicken/Indonesia/7/2003 2003 H5N1
DQ497646 A/chicken/Sragen/BPPV4/2003 2003 H5N1
DQ497681 A/chicken/Vietnam/28/2003 2003 H5N1
DQ497693 A/chicken/Vietnam/8/2003 2003 H5N1
AY585364 A/duck/Guangxi/22/2001 2001 H5N1
ISDN38260 A/Goose/Viet Nam/113/2001 2001 H5N1
ISDN38261 A/Goose/Viet Nam/324/2001 2001 H5N1

A539G

DQ661910 A/chicken/Afghanistan/1207/2006 2006 H5N1
DQ440535 A/swan/Iran/754/2006 2006 H5N1
DQ412997 A/swan/Italy/179/06 2006 H5N1
ISDN136919 A/swan/Italy/179/2006 2006 H5N1
AB263752 A/whooper swan/Mongolia/2/06 2006 H5N1 DQ320939 A/duck/Vietnam/568/2005 2005 H5N1
AY737289 A/chicken/Guangdong/191/04 2004 H5N1
AY518362 A/duck/China/E319-2/03 2003 H5N1

T796C

AB263752 A/whooper swan/Mongolia/2/06 2006 H5N1
DQ320939 A/duck/Vietnam/568/2005 2005 H5N1
AY585373 A/duck/Guangdong/07/2000 2000 H5N1
AY059476 A/Duck/Hong Kong/ww381/2000 2000 H5N1
AY059477 A/Duck/Hong Kong/ww382/2000 2000 H5N1
AY059478 A/Duck/Hong Kong/ww461/2000 2000 H5N1
AY059479 A/Duck/Hong Kong/ww487/2000 2000 H5N1
AY059480 A/Goose/Hong Kong/ww491/2000 2000 H5N1
DQ092869 A/Pekin duck/Singapore/F59/04/98 1998 H5N2
AF194992 A/Chicken/Italy/9097/97 1997 H5N9
ISDN49024 A/duck/Singapore/3/97 1997 H5N3
AF303057 A/duck/Singapore/Q-F119-3/97 1997 H5N3
S68489 A/turkey/England/50-92/91 1991 H5N1
AF082042 A/Duck/Potsdam/1402-6/86 1986 H5N2
CY006036 A/duck/Potsdam/2216-4/1984 1984 H5N6
AF082041 A/Duck/Potsdam/2216-4/84 1984 H5N6
M18450 A/Duck/Ireland/113/83 1983 H5N8
M18451 A/Turkey/Ireland/1378/83 1983 H5N8
AF082039 A/Duck/Hong Kong/698/79 1979 H5N3
AF290443 A/Duck/Ho Chi Minh/14/78 1978 H5N3
CY005575 A/duck/Hong Kong/342/1978 1978 H5N2
U20475 A/duck/Hong Kong/342/78 1978 H5N2
CY006028 A/goose/Hong Kong/23/1978 1978 H5N3
AF082038 A/Duck/Hong Kong/205/77 1977 H5N3
AB241615 A/duck/Miyagi/54/76 1976 H5N3

T868C

DQ661910 A/chicken/Afghanistan/1207/2006 2006 H5N1
DQ440535 A/swan/Iran/754/2006 2006 H5N1
DQ412997 A/swan/Italy/179/06 2006 H5N1
ISDN136919 A/swan/Italy/179/2006 2006 H5N1
AB263752 A/whooper swan/Mongolia/2/06 2006 H5N1 DQ104701 A/duck broiler/Malaysia/F118/08/04 2004 H5N2
DQ122147 A/duck broiler/Malaysia/F189/07/04 2004 H5N2
AB241624 A/duck/Hokkaido/101/04 2004 H5N3
AB241625 A/duck/Hokkaido/193/04 2004 H5N3
AB241626 A/duck/Hokkaido/299/04 2004 H5N3
AJ715872 A/Hanoi/03/2004 2004 H5N1
AY651335 A/Viet Nam/3046/2004 2004 H5N1
ISDN40278 A/Viet Nam/3212/2004 2004 H5N1
AJ632269 A/chicken/France/03426a/03 2003 H5N2
DQ497679 A/chicken/Vietnam/20/2003 2003 H5N1
DQ320938 A/chicken/Vietnam/27/2003 2003 H5N1
DQ497681 A/chicken/Vietnam/28/2003 2003 H5N1
DQ497693 A/chicken/Vietnam/8/2003 2003 H5N1
AY995885 A/mallard/Sweden/21/02 2002 H5N2
AY995895 A/mallard/Sweden/58/02 2002 H5N3
AF194169 A/Chicken/Italy/312/97 1997 H5N2

A1300G

AB263752 A/whooper swan/Mongolia/2/06 2006 H5N1
(plus many other H5N1 isolates)

C1330T

DQ661910 A/chicken/Afghanistan/1207/2006 2006 H5N1
AB263752 A/whooper swan/Mongolia/2/06 2006 H5N1
DQ497651 A/chicken/Gunung Kidal/BBVW/2005 2005 H5N1
DQ497643 A/chicken/Magetan/BBVW/2005 2005 H5N1
DQ320933 A/chicken/Wajo/BBVM/2005 2005 H5N1
DQ497659 A/duck/Parepare/BBVM/2005 2005 H5N1
DQ387854 A/mallard/Bavaria/1/2005 2005 H5N2
DQ647648 A/ostrich/South Africa/1/2004 2004 H5N2
DQ007623 A/Anas platyrhynchos/Chany Lake 2003 H5N3
AY995886 A/mallard/Sweden/22/02 2002 H5N9
AY995887 A/mallard/Sweden/27/02 2002 H5N9
AY995888 A/mallard/Sweden/28/02 2002 H5N9
AY995889 A/mallard/Sweden/31/02 2002 H5N2
AY995890 A/mallard/Sweden/37/02 2002 H5N9
AY995891 A/mallard/Sweden/39/02 2002 H5N3
AY995892 A/mallard/Sweden/40/02 2002 H5N6
AY995893 A/mallard/Sweden/49/02 2002 H5N9
AY995894 A/mallard/Sweden/52/02 2002 H5N9
AY995897 A/mallard/Sweden/79/02 2002 H5N9
AY995898 A/mallard/Sweden/80/02 2002 H5N9
AJ621807 A/duck/Primorie/2633/01 2001 H5N3
AY075030 A/Goose/Hong Kong/3014.5/2000 2000 H5N1
AY059482 A/Goose/Hong Kong/3014.8/2000 2000 H5N1
AY684894 A/mallard/Netherlands/3/99 1999 H5N2
AJ305306 A/chicken/Italy/8/98 1998 H5N2
AF194169 A/Chicken/Italy/312/97 1997 H5N2
AF194990 A/Chicken/Italy/367/97 1997 H5N2
AF194992 A/Chicken/Italy/9097/97 1997 H5N9
AF194991 A/Guinea Fowl/Italy/330/97 1997 H5N2

G1562T

AB263752 A/whooper swan/Mongolia/2/06 2006 H5N1 DQ497642 A/chicken/Malang/BBVet-IV/2004 2004 H5N1
DQ497653 A/chicken/Purwakarta/BBVet-IV/2004 2004 H5N1

C1618T

DQ661910 A/chicken/Afghanistan/1207/2006 2006 H5N1
ISDN133364 A/Turkey/65596/06 2006 H5N1
AB263752 A/whooper swan/Mongolia/2/06 2006 H5N1
DQ320910 A/chicken/Hunan/999/2005 2005 H5N1
DQ095630 A/Duck/Hunan/114/05 2005 H5N1
DQ320902 A/duck/Hunan/127/2005 2005 H5N1
DQ320903 A/duck/Hunan/139/2005 2005 H5N1
DQ320904 A/duck/Hunan/149/2005 2005 H5N1
DQ320905 A/duck/Hunan/152/2005 2005 H5N1
DQ320906 A/duck/Hunan/157/2005 2005 H5N1
DQ320907 A/duck/Hunan/160/2005 2005 H5N1
DQ320908 A/duck/Hunan/166/2005 2005 H5N1
DQ320909 A/duck/Hunan/182/2005 2005 H5N1
DQ095631 A/Duck/Hunan/191/05 2005 H5N1
DQ387854 A/mallard/Bavaria/1/2005 2005 H5N2
AF509025 A/Chicken/Hong Kong/715.5/01 2001 H5N1
AY221524 A/Chicken/Hong Kong/FY150/01 2001 H5N1
AF509019 A/Chicken/Hong Kong/FY150/01 2001 H5N1
AY221523 A/Chicken/Hong Kong/FY150/01-MB 2001 H5N1
AF509016 A/Chicken/Hong Kong/FY77/01 HA 2001 H5N1
AY221522 A/Chicken/Hong Kong/NT873.3/01 2001 H5N1
AY221521 A/Chicken/Hong Kong/NT873.3/01-MB 2001 H5N1
AY221526 A/Pheasant/Hong Kong/FY155/01 2001 H5N1
AF509020 A/Pheasant/Hong Kong/FY155/01 2001 H5N1
AY221525 A/Pheasant/Hong Kong/FY155/01-MB 2001 H5N1
M18450 A/Duck/Ireland/113/83 1983 H5N8
M18451 A/Turkey/Ireland/1378/83 1983 H5N8
X07869 A/chicken/Scotland/59 1959 H5N1
X07826 A/Chicken/Scotland/59 1959 H5N1

»²¹Í2.¡¡Àij¤³ô¤ÎÊÑ°Û²Õ½ê

²¼µ­¤ÎÄ̤ꡣ
RNA¥Õ¥é¥°¥á¥ó¥È(RNA fragments)1.PB2
A1398G T1460C¡¡

RNA¥Õ¥é¥°¥á¥ó¥È2.PB1
T87C C557T G1362T T2196C¡¡

RNA¥Õ¥é¥°¥á¥ó¥È3.PA
T147C G228A T571C T1594C G1825G¡¡

RNA¥Õ¥é¥°¥á¥ó¥È4.HA
G59A¡¡ C796T A1300G¡¡G1562T¡¡

RNA¥Õ¥é¥°¥á¥ó¥È5.NP
C74T G343A ¡¡

RNA¥Õ¥é¥°¥á¥ó¥È6.NA
C162T C979T G1361A¡¡

RNA¥Õ¥é¥°¥á¥ó¥È7.MP
C559A¡¡

RNA¥Õ¥é¥°¥á¥ó¥È8.NS
T41A A849G A851G¡¡
G59A, T211C, C268T, A539G, C796T, T868C, A1300G, C1330T, G1562T, C1618T.

»²¾È¡ÖTuva and Mongolia H5N1 Bird Flu Sequences Are Similar¡×

A/whooper swan/Mongolia/2/2006¤Î°äÅÁ»ÒÇÛÎó¤Ë¤Ä¤¤¤Æ¤Ï¡¢¤³¤Î¥µ¥¤¥È¤´»²¾È

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2007/01/19 Friday

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Filed under: ̤ʬÎà — ´ÉÍý¿Í @ 21:12:53

2007/01/19(Fri)
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¡ÖFlu Wiki 2 - Forum - RESRRKKR¡×
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¡ÖEvolution and Spread of Fujian H5N1 In China¡×
¡ÖA list of relevant mutation position ¡×
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¡ÖH5N1 Confirmed On South Korean Farm¡×

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H5N1¤Îreceptor-binding domain (RBD)(ÆüËܸì¤Ç¤Ï¡¢¡Ö¼õÍÆÂηë¹ç¥É¥á¥¤¥ó¡×¤È¤Ç¤âÌõ¤¹¤Î¤Ç¤·¤ç¤¦¤«¡£)¤Ç¤ÎÊÑ°Û¤¬¡¢¥Ø¥Þ¥°¥ë¥Á¥Ë¥ó¤ò¥Ò¥È¼õÍÆÂΤ˷ë¹ç¤·°×¤¯¤·¡¢¿Í¤Ø¤Î´¶À÷¤ÎÍưפµ¤ò·èÄê¤Å¡«¤±¤ë¤È¤µ¤ì¤Æ¤¤¤ë¡£

¤³¤Îreceptor-binding site¤Ï¡¢£È£Á¤Ë¤è¤Ã¤Æ°Û¤Ê¤ê¡¢
H3¡¡numbering system¤ò¤Ä¤«¤Ã¤Æ¤ß¤ë(H5¤Î¾ì¹ç¤Ï¡¢¥Ý¥¸¥·¥ç¥ó¥Ê¥ó¥Ð¡¼¤¬¡¢¤³¤ì¤È°Û¤Ê¤Ã¤Æ¤¯¤ë¤Î¤Ç¡¢¤´Ãí°Õ¡£)¤È¡¢
amino acids position ¤Î¡¡98, 134–138, 153, 155,183, 190, 194, 195¡¢224–229 ¤Ê¤É¤È¤µ¤ì¤Æ¤¤¤ë¡£

¤³¤Î¤¦¤Á¡¢position 190¤Þ¤Ç¤ò¾åή(upstream)¡¢position 190°Ê¹ß¤ò²¼Î®(downstream)¤È¤·¤Æ¤¤¤ë¤è¤¦¤À¡£

¤³¤Î receptor binding domain ¤Ë¤ª¤±¤ë°äÅÁ»Ò¤Î¥·¡¼¥±¥ó¥¹¤¬¡¢¿Í¤Ø¤Î´¶À÷À­¤ò·è¤á¤ë¤â¤Î¤È¤µ¤ì¤Æ¤¤¤ë¡£

»²¾È¡ÖThe index influenza A virus subtype H5N1¡¡isolated from a human in 1997 differs in its¡¡receptor-binding properties from a virulent¡¡avian influenza virus¡×
¡ÖQinghai H5N1 Receptor Binding Domain Changes In Middle East¡×
¡ÖH5N1 Acquisition Matches Influenza B Receptor Binding Domain¡×

¤³¤ì¤Þ¤ÇÊÑ°Û¤¬¸«¤é¤ì¤¿ receptor binding domain ¤Ï¡¢²¼µ­¤Î¤È¤ª¤ê¤Ç¤¢¤ë¡£

¤Ê¤ª¡¢¤³¤Î¸«Êý¤Ç¤¹¤¬¡¢¤¿¤È¤¨¤Ð¡¢¡ÖD187N ¡×¤È½ñ¤¤¤Æ¤¢¤ë¾ì¹ç¤Ë¤Ï¡¢¡Ö¥Ý¥¸¥·¥ç¥ó187¤Ë¤ª¤¤¤Æ¡¢D(¥¢¥¹¥Ñ¥é¥®¥ó»À)¤«¤éN(¥¢¥¹¥Ñ¥é¥®¥ó)¤ËÊÑ°Û¤·¤¿¡×¤È¤¤¤¦¤³¤È¤ò»Ø¤·¤Þ¤¹¡£

¥¢¥ß¥Î»Àµ­¹æ¤Ë¤Ä¤¤¤Æ¤Ï¡¢¤³¤Î¥µ¥¤¥È¡ÖDNA ¤È¥¢¥ß¥Î»À¤Î°Å¹æɽ ¡×¤ò¤´»²¾È¤¯¤À¤µ¤¤¡£

Amino acid residue position 190¤Î¾åή(upstream)¡¡

amino acid at position¡¡186(position186¤Ç¤Î¥¢¥ß¥Î»ÀÇÛÎóÊÑ°Û¡¢°Ê²¼Æ±¤¸)-
N186K(QinghaiʬΥ³ô¡¡AzerbaijanʬΥ³ô)(¥¢¥¹¥Ñ¥é¥®¥ó¤«¤é¥ê¥·¥ó¤ØÊÑ°Û)
or
N186S(QinghaiʬΥ³ô)(¥¢¥¹¥Ñ¥é¥®¥ó¤«¤é¥»¥ê¥ó¤ØÊÑ°Û)

amino acid at position 187(position187¤Ç¤Î¥¢¥ß¥Î»ÀÇÛÎóÊÑ°Û¡¢°Ê²¼Æ±¤¸)-
D187N (HunanʬΥ³ô-isolates-¡¡A/chicken/Hunan/2246/2006¤Ê¤É) (¥¢¥¹¥Ñ¥é¥®¥ó»À¤«¤é¥¢¥¹¥Ñ¥é¥®¥ó¤ØÊÑ°Û)

amino acid at position 188-
A188E (ShanxiʬΥ³ô¡¡A/chicken/Shanxi/2/2006¤Ê¤É) (¥¢¥é¥Ë¥ó¤«¤é¥°¥ë¥¿¥ß¥ó»À¤ØÊÑ°Û)

amino acid at position 189-
A189T (ShanxiʬΥ³ô¡¡A/chicken/Shanxi/2/2006¤Ê¤É) (¥¢¥é¥Ë¥ó¤«¤é¥¹¥ì¥ª¥Ë¥ó¤ØÊÑ°Û)
or
A189E (HunanʬΥ³ô¡¡A/chicken/Hunan/2246/2006¤Ê¤É) (¥¢¥é¥Ë¥ó¤«¤é¥°¥ë¥¿¥ß¥ó»À¤ØÊÑ°Û)

Amino acid residue position 190¤Î²¼Î®(downstream)

amino acid at position 190-
E190D¡¡( VietnamʬΥ³ô¡¡A/Vietnam/1203/2004¤Ê¤É) (¥°¥ë¥¿¥ß¥ó»À¤«¤é¥¢¥¹¥Ñ¥é¥®¥ó»À¤ØÊÑ°Û)
or
E190V ( VietnamʬΥ³ô) (¥°¥ë¥¿¥ß¥ó»À¤«¤é¥Ð¥ê¥ó¤ØÊÑ°Û)

amino acid at position 192-
T192I (Shanxi ¡õ¡¡Hunan¡¡Ê¬Î¥³ô¡¡A/chicken/Shanxi/2/2006¡¡A/chicken/Hunan/2246/2006¤Ê¤É¡¡) (¥¹¥ì¥ª¥Ë¥ó¤«¤é¥¤¥½¥í¥¤¥·¥ó¤ØÊÑ°Û)

amino acid at position 194-
L194I (Shanxi ¡õ¡¡Hunan¡¡Ê¬Î¥³ô¡¡A/chicken/Shanxi/2/2006¡¡¡¡A/chicken/Hunan/2246/2006¤Ê¤É) (¥í¥¤¥·¥ó¤«¤é¥¤¥½¥í¥¤¥·¥ó¤ØÊÑ°Û)

amino acid at position¡¡196-
Q196R(QinghaiʬΥ³ô)(¥°¥ë¥¿¥ß¥ó¤«¤é¥¢¥ë¥®¥Ë¥ó¤ØÊÑ°Û)

amino acid at position 214-
V214M (Shantou ʬΥ³ô¡¡A/goose/Shantou/2086/2006¤Ê¤É) (¥Ð¥ê¥ó¤«¤é¥á¥Á¥ª¥Ë¥ó¤ØÊÑ°Û)

amino acid at position 220-
R220K (Shanxi ʬΥ³ô¡¡¡¡A/chicken/Shanxi/2/2006¤Ê¤É) (¥¢¥ë¥®¥Ë¥ó¤«¤é¥ê¥·¥ó¤ØÊÑ°Û)

amino acid at position 222-
K222Q (Shanxi ʬΥ³ô¡¡A/chicken/Shanxi/2/2006¤Ê¤É) (¥ê¥·¥ó¤«¤é¥°¥ë¥¿¥ß¥ó¤ØÊÑ°Û)
or
K222R (Shantou ʬΥ³ô¡¡A/goose/Shantou/2086/2006¤Ê¤É) (¥ê¥·¥ó¤«¤é¥¢¥ë¥®¥Ë¥ó¤ØÊÑ°Û)

amino acid at position 223-
V223I (Shantou ʬΥ³ô¡¡A/goose/Shantou/2086/2006¤Ê¤É) (¥Ð¥ê¥ó¤«¤é¥¤¥½¥í¥¤¥·¥ó¤ØÊÑ°Û)

amino acid at position 225-
G225D ( VietnamʬΥ³ô¡¡A/Vietnam/1203/2004¤Ê¤É) (¥°¥ê¥·¥ó¤«¤é¥¢¥¹¥Ñ¥é¥®¥ó»À¤ØÊÑ°Û)

amino acid at position 226-
Q226L ( VietnamʬΥ³ô¡¡A/Vietnam/1203/2004) (¥°¥ë¥¿¥ß¥ó¤«¤é¥í¥¤¥·¥ó¤ØÊÑ°Û)

amino acid at position 227-
S227R (Shantou ʬΥ³ô¡¡¡¡QinghaiʬΥ³ô¡¡¡¡A/goose/Shantou/2086/2006¤Ê¤É) (¥»¥ê¥ó¤«¤é¥¢¥ë¥®¥Ë¥ó¤ØÊÑ°Û)¡¡
or
S227N¡ÊTurkey¡¡& VietnamʬΥ³ô¡¡ A/turkey/Kfar Warburg/1224/03 A/Vietnam/1203/2004¤Ê¤É¡¢¤³¤Î³ô¤Ï¡¢H9N2 ¤ÈH5N1¤È¤¬¥ß¥Ã¥¯¥¹¤·¤¿¤â¤Î¤È¤¤¤ï¤ì¤Æ¤¤¤ë¡£¡Ë (¥»¥ê¥ó¤«¤é¥¢¥¹¥Ñ¥é¥®¥ó¤ØÊÑ°Û)

amino acid at position 228-
G228S¡¡( VietnamʬΥ³ô A/Vietnam/1203/2004 ¤Ê¤É) (¥°¥ê¥·¥ó¤«¤é¥»¥ê¥ó¤ØÊÑ°Û)

amino acid at position 230-
M230I ¡ÊEgyptʬΥ³ô¡¡QinghaiʬΥ³ô¡¡ZhejiangʬΥ³ô¡¡A/Egypt/12374-NAMRU3/2006¡¡A/duck/Zhejiang/bj/2002(¡¡¤Ê¤É¡¡¡Ë (¥á¥Á¥ª¥Ë¥ó¤«¤é¥¤¥½¥í¥¤¥·¥ó¤ØÊÑ°Û)

»²¹Í¡ÖH5N1 Fujian Cleavage Site Evolution¡×
¡ÖOIE Hong Kong Report ¡×
¡ÖHunan H5N1 Has Multiple Receptor Binding Domain Changes ¡×
¡ÖA list of relevant mutation position ¡×
¡ÖH5N1 genetic structure¡×
¡ÖIf anyone one is interested in the progress of H5N1 from sources doing histology ¡×
¡ÖQinghai H5N1 Receptor Binding Domain Changes In Middle East¡×

¤Ê¤ª¡¢°Ê²¼¤ÏÈÖ³°¤Ç¤¢¤ë¤¬¡¢¥Ò¥È´¶À÷H5N1¥¦¥¤¥ë¥¹¤Ç¡¢¥¿¥ß¥Õ¥ëÉþÍѤˤè¤Ã¤Æ¥¿¥ß¥Õ¥ëÂÑÀ­¤¬À¸¤¸¤¦¤ëÊѰۤȤ·¤Æ¤Ï¡¢²¼µ­¤Î¤â¤Î¤¬¤¢¤ë¡£

R152K(¥Ý¥¸¥·¥ç¥ó152¤Ç¤Î¥¢¥ë¥®¥Ë¥ó¤«¤é¥ê¥·¥ó¤Ø¤ÎÊÑ°Û¡¢N1)( B/Memphis/20/96¡¡¡¡¤Ê¤É)
H274Y(¥Ý¥¸¥·¥ç¥ó274¤Ç¤Î¡¢¥Ò¥¹¥Á¥¸¥ó¤«¤é¥Á¥í¥·¥ó¤Ø¤ÎÊÑ°Û¡¢N1) (A/Texas/36/91¤Ê¤É)¡¢
N294S(¥Ý¥¸¥·¥ç¥ó294¤Ç¤Î¥¢¥¹¥Ñ¥é¥®¥ó¤«¤é¥»¥ê¥ó¤Ø¤ÎÊÑ°Û¡¢N1) ¡Ê Qinghai³ô¤Ë¡¢¤³¤ÎÊÑ°Û¤¬¸«¤é¤ì¤¿¤È¤µ¤ì¤Æ¤¤¤ë¤¬¡¢¸ø¼°¤Îȯɽ¤Ï¤Ê¤¤¤è¤¦¤À¡£¡Ë

¤Ê¤ª¡¢¤³¤Î¥µ¥¤¥È¡ÖSeasonal & Pandemic Influenza¡×¤Ë¤è¤ì¤Ð¡¢ÆüËܤξì¹ç¡¢E119V,R292K,N294S¤ÎÊѰۤϡ¢H3N2¥¦¥¤¥ë¥¹¤ËÂФ·¤Æ¡¢18¥Ñ¡¼¥»¥ó¥È¤Î¾®»ù¤¬ÂÑÀ­¤ò¼¨¤·¡¢H274Y¤ÎÊѰۤϡ¢H1N1¥¦¥¤¥ë¥¹¤ËÂФ·¤Æ¡¢18¥Ñ¡¼¥»¥ó¥È¤Î¾®»ù¤¬ÂÑÀ­¤ò¼¨¤·¤¿¤È¤µ¤ì¤ë¡£

¥¦¥¤¥ë¥¹¤´¤È¤Î¹¹¤Ê¤ë¾ÜºÙ¤Ê°äÅÁ»ÒÇÛÎó¤Ë¤Ä¤¤¤Æ¤Ï¡¢¡ÖThe Influenza Sequence Database¡×¤ò¤´»²¾È
¤¿¤È¤¨¤Ð¡¢¤³¤ì¤Ë¡¢¥¦¥¤¥ë¥¹Ì¾¡ÖA/Bar headed goose/Qinghai/1A/2005 ¡×¤òÆþÎϤ¹¤ë¤È¡¢Raw Sequence¤¬ÆÀ¤é¤ì¤ë¡£

¤³¤ì¤Ë¤è¤Ã¤ÆÆÀ¤é¤ì¤¿¡ÖRaw Sequence¡×¤ò¡Öamino acids¡×ÇÛÎó¤Ç¸«¤ë¤Ë¤Ï¡¢¤µ¤é¤Ë¡¢¡ÖSequence Manipulation Suite¡×¤ä¡ÖTranslation of DNA to an Amino Acid Sequence¡×¤ä¡ÖBCM Search Launcher¡×¤ä¡ÖTranslate a DNA Sequence¡×¤ä¡ÖTranslation of DNA to an Amino Acid Sequence¡×¤Ê¤É¤ÎTranslation¤Ë¤«¤±¤ëɬÍפ¬¤¢¤ë¡£

¡ÖRaw Sequence¡×¤ÎTranslation¤Ë¤Ï¡¢¡ÖGeneious ¡×¤Ê¤É¡¢¥Õ¥ê¡¼¥½¥Õ¥È¤Î¥À¥¦¥ó¥í¡¼¥É¤Ë¤è¤Ã¤Æ¤â¡¢²Äǽ¤Ç¤¢¤ë¡£

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¥¯¥ì¡¼¥É¤´¤È¤Î°äÅÁ»ÒÇÛÎó¤Î°ã¤¤¤Ï¡¢¤³¤Î¥µ¥¤¥È¡ÖEvolution of H5N1 avian influenza viruses in Asia¡×¤ò¤´»²¾È

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»²¾È¡ÖQinghai H5N1 Confirmed On South Korean Farms¡×

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»²¾È¡ÖBird flu vaccine may be more protective than thought¡×

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