¤³¤Î¥µ¥¤¥È¤Ë¤ª¤¤¤Ç¤¤¤¿¤À¤¤¤¿Êý¤Ø
¤³¤Î¾ðÊó¤Ï11·î22Æü»þÅÀ¤Ç¤Î¾ðÊó¤Ç¤¹¡£
º£²ó¤Î¥¦¥¯¥é¥¤¥Ê¤ò½é¤á¤È¤·¤¿H1N1¿··¿¥¤¥ó¥Õ¥ë¥¨¥ó¥¶¡¦¥¦¥¤¥ë¥¹¤ÎD225GÊѰۤˤĤ¤Þ¤·¤Æ¤Ï¡¢¤³¤Î¥µ¥¤¥È°Ê³°¤Ë¤â¡¢»ä¤Î¥Ö¥í¥°µ»ö¤Ç¤Ï¡¢²¼µ¤Ç¼è¤ê¾å¤²¤Æ¤ª¤ê¤Þ¤¹¤Î¤Ç¡¢¤¢¤ï¤»¤Æ¤´»²¾È¤¯¤À¤µ¤¤¡£
¤¢¤¿¤é¤·¤¤µ»ö½ç¤Ç¤¹¡£
D225GÊÑ°ÛH1N1¿··¿¥¤¥ó¥Õ¥ë¥¨¥ó¥¶¡¦¥¦¥¤¥ë¥¹¤ËÂФ·¤Æ¥ï¥¯¥Á¥óÉÔÁ´¤¢¤ê¤ÈWHO³Îǧ (11·î28Æü»þÅÀ)
¥¦¥¯¥é¥¤¥Ê¡¦¥Î¥ë¥¦¥§¥¤¡¦¹á¹Á¶¦Ä̤ÎH1N1¿··¿¥¤¥ó¥Õ¥ë¥¨¥ó¥¶¡¦¥¦¥¤¥ë¥¹ÊѰۤˤĤ¤¤Æ(11·î25Æü»þÅÀ)
¥¦¥¯¥é¥¤¥Ê¤ÇÂçÎÌ»àË´¤Î¿··¿¥¤¥ó¥Õ¥ë¥¨¥ó¥¶¡¦¥¦¥¤¥ë¥¹¤Ï¡¢ÇÙÁÈ¿¥¤Ç½¸Ã椷ÊÑ°Û¤·¤Æ¤¤¤ë¤³¤È¤¬È½ÌÀ(11·î19Æü»þÅÀ)
¥¦¥¯¥é¥¤¥Ê¤ÇH1N1¿··¿¥¤¥ó¥Õ¥ë¥¨¥ó¥¶´¶À÷¼Ô¤¬¸ÆµÛ´ï¼À´µ¤ÇÂçÎÌ»àË´ (11·î9Æü»þÅÀ)
2009/11/22(Sun)
¡¡
¡Ä»¥¤¥ó¥Õ¥ë¥¨¥ó¥¶¡¦¥¦¥¤¥ë¥¹¤Ï¥·¥¢¥ë»À¤¬¥¬¥é¥¯¥È¡¼¥¹¤Ë¦Á 2,3 ·ë¹ç¤·¤¿¤â¤Î¡ÊSA¦Á2,3Gal¡Ë¤òǧ¼±¤·¡¢
¥Ò¥È¥¤¥ó¥Õ¥ë¥¨¥ó¥¶¡¦¥¦¥¤¥ë¥¹¤Ï¼ç¤È¤·¤Æ¥·¥¢¥ë»À¤¬¥¬¥é¥¯¥È¡¼¥¹¤Ë¦Á2,6·ë¹ç¤·¤¿¤â¤Î (SA ¦Á2,6Gal )¤òǧ¼±¤¹¤ë¡£
¢¥Ò¥È¤Î¥ì¥»¥×¥¿¡¼¤ÎʬÉۤϡ¢Ä»¥¤¥ó¥Õ¥ë¥¨¥ó¥¶¡¦¥¦¥¤¥ë¥¹¤Î¾ì¹ç¤È¡¢¥Ò¥È¥¤¥ó¥Õ¥ë¥¨¥ó¥¶¡¦¥¦¥¤¥ë¥¹¤Î¾ì¹ç¤È¤Ç¤Ï°Û¤Ê¤ë¡£
£¥Ò¥È¥¤¥ó¥Õ¥ë¥¨¥ó¥¶¡¦¥¦¥¤¥ë¥¹¤Î¾ì¹ç¤Î¥Ò¥È¤Î¥ì¥»¥×¥¿¡¼¤ÎʬÉۤϡ¢¡¢¥Ò¥È¤Î¾åÉôµ¤Æ»¤Î¾åÈéºÙ˦¤Ë¤·¤«¤Ê¤¤¡£
¤Ä»¥¤¥ó¥Õ¥ë¥¨¥ó¥¶¡¦¥¦¥¤¥ë¥¹¤Î¾ì¹ç¤Î¥Ò¥È¤Î¥ì¥»¥×¥¿¡¼¤ÎʬÉۤϡ¢¥Ò¥È¤Î¸ÆµÛ´ï¤Î¿¼Éô¡Ê¸ÆµÛºÙµ¤´É»Ù¤ÈÇÙ˦ºÙ˦¤Î°ìÉô¡Ë¤Ë¡¢Â¿¤¯Â¸ºß¤¹¤ë¡£
¥¤³¤Î¥Ò¥È¤Î¸ÆµÛ´ï¤Ë¤ª¤±¤ë¥Ò¥È¡¦¥¦¥¤¥ë¥¹¤ÈÄ»¥¤¥ó¥Õ¥ë¥¨¥ó¥¶¡¦¥¦¥¤¥ë¥¹¤Î¥ì¥»¥×¥¿¡¼Ê¬ÉÛ¤ÎÁê°ã¤Ï¡¤H5N1 ¥¦¥¤¥ë¥¹¤¬¿Í¤«¤é¿Í¤ØÅÁÇŤ·¤Ë¤¯¤¤»ö¼Â¤Ë¤â´Ø·¸¤·¤Æ¤¤¤ë¡£
¦¥Ò¥È¤¬Ä»¥¤¥ó¥Õ¥ë¥¨¥ó¥¶¡¦¥¦¥¤¥ë¥¹¤ò¸úΨ¤è¤¯ÅÁÇŤ¹¤ë¤¿¤á¤Ë¤Ï¡¤HA ¤¬¥Ò¥È¡¦¥¦¥¤¥ë¥¹¤Î¥ì¥»¥×¥¿¡¼¤òǧ¼±¤Ç¤¤ë¤è¤¦¤ËÊÑ°Û¤¹¤ëɬÍפ¬¤¢¤ë¡£
§¥Ò¥È¤¬¡¢Ä»¥¤¥ó¥Õ¥ë¥¨¥ó¥¶¡¦¥¦¥¤¥ë¥¹¤Ë´¶À÷¤¹¤ë¤È¡¢½ÅÆƤʲ¼Éô¸ÆµÛ´ï¾ã³²¤ò°ú¤µ¯¤³¤¹¤³¤È¤¬¤¢¤ë¤Î¤Ï¡¢¤³¤Î¥ì¥»¥×¥¿¡¼¤ÎʬÉÛ(¸ÆµÛ´ï¤Î¿¼Éô¤ËÄ»¥¤¥ó¥Õ¥ë¥¨¥ó¥¶¡¦¥¦¥¤¥ë¥¹¤Î¥ì¥»¥×¥¿¡¼¤¬¤¢¤ë¡£)¤Î°ã¤¤¤È¡¢¥¦¥¤¥ë¥¹¤ÎÊѰۤˤè¤ë¤È¤³¤í¤¬Â礤¤¤È¸«¤é¤ì¤ë¡£
¨º£²ó¡¢¥¦¥¯¥é¥¤¥Ê¤Ç¤Î¿··¿¥¤¥ó¥Õ¥ë¥¨¥ó¥¶´¶À÷¼Ô¤¬¡¢¤¤¤º¤ì¤â½ÅÆƤǡ¢¤·¤«¤â¡¢¤½¤Î»àË´¼Ô¤ò´Þ¤á¤¿½ÅÆƼԤÎÇ٤ǤΥ¦¥¤¥ë¥¹¤¬¡¢¤¤¤º¤ì¤â¡¢D225GÊÑ°Û¤ò¤ª¤³¤·¤ª¤ê¡¢¾åµ¤Æ»¤Ç¤ÎD225GÊÑ°Û¤¬1¤Ä¤·¤«¤Ê¤«¤Ã¤¿¤È¤¤¤¦¤³¤È¤¬¡¢¾åµ¤Î¤³¤È¤È´Ø·¸¤¢¤ë¤Î¤«¡£
©¥Ý¥¸¥·¥ç¥ó225ÊѰۤϡ¢H3N2¤Ë¤è¤¯¸«¤é¤ì¤ë¥¢¥Þ¥ó¥¿¥¸¥óÂÑÀÊѰۤǤ¢¤ê¡¢H1N1¤Ë¤ª¤¤¤Æ¤â¡¢·à¾ÉÀ¤òÉÕÍ¿¤·¤¦¤ëÊѰۤǤ¢¤ë¤µ¤ì¤Æ¤¤¤ë¡£
¥¢¥Þ¥ó¥¿¥¸¥óÂÑÀÊѰۤǤ¢¤ë¤³¤È¤È¡¢¥¦¥¯¥é¥¤¥Ê¤È¤Î´Ø·¸¤Ï¤¢¤ë¤Î¤«?
ª¤Þ¤¿¡¢1918ǯ¤Î¥¹¥Ú¥¤¥óÉ÷¼Ù¤Ë¤ª¤¤¤Æ¡¢ºÎ¼è¤µ¤ì¤¿Æó¤Ä¤Î¥¦¥¤¥ë¥¹¡¡A/New York/1/1918 ¤È¡¡A/London/1/1919¡¡¤Ë¤â225¤Ë¤ª¤¤¤Æ¡¢Æ±ÍͤÎD225GÊÑ°Û¤¬¸«¤é¤ì¤¿¤³¤È¤È¤Î´Ø·¸¤Ï¤¢¤ë¤Î¤«¤É¤¦¤«¡£
«1918ǯ¤Î¥¦¥¤¥ë¥¹¤Î¥·¡¼¥±¥ó¥¹Ê¬ÀϤˤª¤¤¤Æ¡¢¼õÍÆÂÎÆÃÀ¤Ï¡¢¡ÖSA ¦Á2,6Gal¡× ¤È¡¢¡ÖSA¦Á2,3Gal¡×¤È¡¢¡ÖSA¦Á2,3Gal¤ÈSA ¦Á2,6Gal¤È¤Îº®¹ç¡×¤È¤Î»°¤Ä¤Î¥¿¥¤¥×¤¬¸«¤é¤ì¤¿¡£
¬¼õÍÆÂÎÆÃÀ¤Î¡ÖSA¦Á2,3Gal¡×¤«¤é¡ÖSA ¦Á2,6¡×¤Ø¤ÎÊѲ½¼«ÂΤϡ¢·à¾ÉÀ¤òÉÕÍ¿¤¹¤ë¤â¤Î¤Ç¤Ï¤Ê¤¤¡£
¡ÖSA¦Á2,3Gal¤ÈSA ¦Á2,6Gal¤È¤Îº®¹ç¡×¤Ë¤Ä¤¤¤Æ¤Ï¤É¤¦¤«?
CDC¤ÎNancy J. Cox »á¤ò¤Ï¤¸¤á¤È¤¹¤ë59¿Í¤«¤é¤Ê¤ë¸¦µæ¥Á¡¼¥à¤ÎH1N1 ¿··¿¥¤¥ó¥Õ¥ë¥¨¥ó¥¶¥¦¥¤¥ë¥¹¤Î°äÅÁ»ÒʬÀϤˤè¤ì¤Ð¡¢8¤Ä¤Î¥»¥°¥á¥ó¥È¤Î¤¦¤Á¡¢¥Ø¥Þ¥°¥ë¥Á¥Ë¥ó(H)¤ò´Þ¤à3¤Ä¤Î°äÅÁ»Ò¥»¥°¥á¥ó¥È¤Ï¡¢1918ǯ¤Î¥¹¥Ú¥¤¥óÉ÷¼Ù¤ÎH1N1¤ËͳÍ褹¤ë¤â¤Î¤Ç¤¢¤ê¡¢¤½¤Î¸å¡¢¤º¤Ã¤ÈÆڤ˸ºß¤·¤Æ¤¤¤¿¤â¤Î¤Ç¤¢¤ë¤¬¡¢¤½¤Î´Ö¤Ë¤ª¤¤¤Æ¤â¡¢ÊѰۤϤ·¤Æ¤¤¤Ê¤«¤Ã¤¿¤È¤·¤Æ¤¤¤ë¡£
°äÅÁ»Ò¥»¥°¥á¥ó¥È¤Ç¤Ï¡¢¥Ý¥ê¥á¥é¡¼¥¼B(PB)°äÅÁ»Ò¤Ï¥Ò¥ÈͳÍ衢¾¤ÎÆó¤Ä¤ÏĻͳÍè¤Ç¤¢¤Ã¤¿¤È¤·¤Æ¤¤¤ë¡£
¤Þ¤¿¡¢1918ǯ¤ÎH1N1¤ÈH5N1¤È¤Ï¡¢ÆÇÀ¤¬¤¢¤ë¤³¤È¤ò¼¨¤¹°äÅÁ»Ò¥»¥°¥á¥ó¥È¤ò¡¢Æ±¤¸NS1¥»¥°¥á¥ó¥È¤Ë¤ª¤¤¤Æͤ·¤Æ¤¤¤ë¤¬¡¢º£²ó¤Î¿·H1N1¤Ï¡¢¤½¤¦¤Ç¤Ï¤Ê¤¤¤È¤¤¤¦¡£
´¶À÷À¤ò¼¨¤¹°äÅÁ»Ò¥»¥°¥á¥ó¥È¤Ë¤ª¤¤¤Æ¤â¡¢º£²ó¤Î¿·H1N1¤Ï¡¢1918ǯ¤ÎH1N1¤Ë¤¢¤Ã¤¿¤â¤Î¤ò¼º¤Ã¤Æ¤¤¤ë¤È¤¤¤¦¡£
»²¹Í¡¡´ØÏ¢¤¹¤ë»ä¤Î¥Ö¥í¥°µ»ö
¡Ö¤ä¤Ï¤ê¿··¿¤Ç¤Ï¤Ê¤«¤Ã¤¿¡¢º£²ó¤ÎH1N1¿··¿¥¤¥ó¥Õ¥ë¥¨¥ó¥¶¡¦¥¦¥¤¥ë¥¹¡×
¡Ö¥¦¥¯¥é¥¤¥Ê¤ÇÂçÎÌ»àË´¤Î¿··¿¥¤¥ó¥Õ¥ë¥¨¥ó¥¶¡¦¥¦¥¤¥ë¥¹¤Ï¡¢ÇÙÁÈ¿¥¤Ç½¸Ã椷ÊÑ°Û¤·¤Æ¤¤¤ë¤³¤È¤¬È½ÌÀ¡×
¡Ö¥¦¥¯¥é¥¤¥Ê¤ÇH1N1¿··¿¥¤¥ó¥Õ¥ë¥¨¥ó¥¶´¶À÷¼Ô¤¬¸ÆµÛ´ï¼À´µ¤ÇÂçÎÌ»àË´¡×
¤½¤Î¾´ØÏ¢¥µ¥¤¥È
¡ÖRole of sialic acid binding specificity of the 1918 influenza virus hemagglutinin protein in virulence and pathogenesis in mice.¡×
¡Övirus: alpha2,6-sialyllactose-avian flu citations¡×
¡¡
¤ªÃΤ餻:
ÆüËܤ«¤é¥·¥«¥´¤Î¥ª¥×¥·¥ç¥óÇäÇ㤬¤Ç¤¤ë¤¿¤á¤Î¥Þ¥Ë¥å¥¢¥ë ¡Ö¥·¥«¥´¡¦¥ª¥×¥·¥ç¥óÇäÇãÀïά¥Þ¥Ë¥å¥¢¥ë¡× (A4ÈÇ297¥Ú¡¼¥¸¡¢5,900±ß¡¢CD-ROMÈǤÏ4,800±ß) ¤ò¤³¤Î¤¿¤Ó½ñ¤¾å¤²¡¢È¯´©¤·¤Þ¤·¤¿¡£ ÆâÍÆ¡¦Ìܼ¡¤Î¤´³Îǧ¤ä¤ªµá¤á¤Ë¤Ä¤¤¤Æ¤Ï¡¢¤³¤Á¤é¤ò¥¯¥ê¥Ã¥¯¤·¤Æ¤¯¤À¤µ¤¤¡£ ¤ªÆÁÍѤʥÀ¥¦¥ó¥í¡¼¥ÉÈÇ-ÅŻҽñÀÒPDF¥Õ¥¡¥¤¥ë(297¥Ú¡¼¥¸¡¢3,980±ß)¤´´õ˾¤Î¾ì¹ç¤Ï¡¢¤³¤Á¤é¤ò¥¯¥ê¥Ã¥¯ ¤·¤Æ¤¯¤À¤µ¤¤¡£ |
---|